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Caldwell Jane C.

E-mail: janecaldwellscientist@gmail.com

Jane C. Caldwell, Ph.D., served as a Senior Toxicologist for the U. S. Environmental Protection Agency from 1991 through December 2016. She received her B.S. in Biology from the University of Kentucky and her Ph.D. from the Curriculum of Toxicology at the University of North Carolina at Chapel Hill. Her areas of expertise include toxicology with emphases on mechanistic analyses of non-cancer and cancer health effects from environmental pollutants at the molecular to organ system level (e.g., brain, liver, hematopoietic system, kidney, and immune system). Areas of specific expertise include many aspects of general toxicology, pollutant-induced pathology, and pharmacokinetics with an academic research background that includes hepatic pathobiology and liver transplantation, organo-metal toxicity [physiologically based pharmacokinetic (PBPK) modeling, neurotoxicity, and pathology], and cancer research.
Jane Caldwell has conducted and contributed to health risk assessments of environmental agents at the national (U.S. Environmental Protection Agency) and international level (International Agency for Research on Cancer). She has developed many high profile risk assessments (e.g., cancer and non-cancer health effects of hazardous air pollutant identified in the Clean Air act and their cumulative exposure impacts; Particulate Matter health effects in support of National Air Quality Standards; and Integrated Risk Information System assessments of trichloroethylene and methyl tertiary-butyl ether). She has also published highly cited journal articles and reviews that include individual pollutants [e.g., di(ethylhexyl)phthalate (DEHP) and trichloroethylene], modes of action hypotheses involving cancers (e.g., lymphoma induction and peroxisome-proliferator activated receptor effects), and the state of the science and application of PBPK modeling to predict human responses from environmental exposures.
International collaborations have included not only cancer assessments but also risk assessment teaching and capacity building in Russia and Ukraine.
Jane C. Caldwell has served on the editorial board of Mutation Research Reviews since 2014 and serves as a peer reviewer and expert in mechanistic analyses and risk assessment for a broad spectrum of high impact journals.


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